The University of Southampton

Prof Julia Gorelik : Non-optical nanoscale functional imaging for studying living cells

Published: 19 October 2018

Please come and join us for the upcoming Bioengineering Seminar ‘Non-optical nanoscale functional imaging for studying living cells’, given by Prof Julia Gorelik. Julia Gorelik is Professor of Cellular Biophysics within the Cardiovascular Science Division at the National Heart and Lung Institute, Imperial College London. The seminar will take place on Friday, 19.10.2018 at 13:00 in room B53/4025. Refreshments, including cakes and coffee, will be served.

Abstract: Cardiac muscle cells (cardiomyocytes) are very structured cells with their main ion channels and receptors not randomly located but instead found in special micro-domains. Heart failure causes disturbance of these micro-domains. A new functional approach combining scanning ion conductance microscopy (SIM) with resonant energy transfer (FRET) measurements will be presented to study cardiac cell isolated by healthy adult rat hearts. The same technique will be applied for rat model of chronic heart failure showing surface morphology and T-tubular structure significantly disrupted. These results represent a great impact in the understanding of the re-arrangement of localized secondary messenger signalling in the sarcolemma of cardiac cells and help to understand the mechanism by which beta blockers work. Info about the speaker:

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